Doubts over the long-term safety of the HIV nucleoside reverse transcriptase inhibitor abacavir and the less commonly used antiretroviral drug didanosine are raised in a research Article. Both drugs were found to be associated with an increased risk of myocardial infarction. Jens Lundgren (University of Copenhagen, Denmark) discusses the study in this week's podcast.

This summary covers the issue of April 3, 2008. Featured are articles on simvastatin with or without ezetimibe in familial hypercholesterolemia, obesity and increased use of health care during pregnancy, a gene for the cblD defect of vitamin B12 metabolism, treatment of vulvar intraepithelial neoplasia with topical imiquimod, and options for slowing the growth of health care costs; review articles on osteoporosis in men and on atopic dermatitis; a Clinical Problem-Solving article describing an unintended consequence; and Perspective articles on guns, the Constitution, and public health and on regulating off-label drug use.

Effect of Rimonabant on Progression of Atherosclerosis in Patients With Abdominal Obesity and Coronary Artery Disease: The STRADIVARIUS Randomized Controlled Trial Steven E. Nissen; Stephen J. Nicholls; Kathy Wolski; Josep Rodés-Cabau; Christopher P. Cannon; John E. Deanfield; Jean-Pierre Després; John J. P. Kastelein; Steven R. Steinhubl; Samir Kapadia; Muhammad Yasin; Witold Ruzyllo; Christophe Gaudin; Bernard Job; Bo Hu; Deepak L. Bhatt; A. Michael Lincoff; E. Murat Tuzcu; for the STRADIVARIUS Investigators JAMA. 2008;299(13):1547-1560. Published online April 1, 2008 (doi:10.1001/jama.299.13.1547). Comparison of Pioglitazone vs Glimepiride on Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes: The PERISCOPE Randomized Controlled Trial Steven E. Nissen; Stephen J. Nicholls; Kathy Wolski; Richard Nesto; Stuart Kupfer; Alfonso Perez; Horacio Jure; Robert De Larochellière; Cezar S. Staniloae; Kreton Mavromatis; Jacqueline Saw; Bo Hu; A. Michael Lincoff; E. Murat Tuzcu; for the PERISCOPE Investigators JAMA. 2008;299(13):1561-1573. Published online March 31, 2008 (doi:10.1001/jama.299.13.1561). Gene Expression Signatures, Clinicopathological Features, and Individualized Therapy in Breast Cancer Chaitanya R. Acharya; David S. Hsu; Carey K. Anders; Ariel Anguiano; Kelly H. Salter; Kelli S. Walters; Richard C. Redman; Sascha A. Tuchman; Cynthia A. Moylan; Sayan Mukherjee; William T. Barry; Holly K. Dressman; Geoffrey S. Ginsburg; Kelly P. Marcom; Katherine S. Garman; Gary H. Lyman; Joseph R. Nevins; Anil Potti JAMA. 2008;299(13):1574-1587. Clinical Crossroads A 21-Year-Old Man With Chronic Pancreatitis Mark P. Callery; Steven D. Freedman JAMA. 2008;299(13):1588-1594. Published online March 4, 2008 (doi:10.1001/jama.299.9.jrr80001). Commentaries 21st-Century Primary Care: New PhysicianEffect of Rimonabant on Progression of Atherosclerosis in Patients With Abdominal Obesity and Coronary Artery Disease: The STRADIVARIUS Randomized Controlled Trial Steven E. Nissen; Stephen J. Nicholls; Kathy Wolski; Josep Rodés-Cabau; Christopher P. Cannon; John E. Deanfield; Jean-Pierre Després; John J. P. Kastelein; Steven R. Steinhubl; Samir Kapadia; Muhammad Yasin; Witold Ruzyllo; Christophe Gaudin; Bernard Job; Bo Hu; Deepak L. Bhatt; A. Michael Lincoff; E. Murat Tuzcu; for the STRADIVARIUS Investigators JAMA. 2008;299(13):1547-1560. Published online April 1, 2008 (doi:10.1001/jama.299.13.1547). Comparison of Pioglitazone vs Glimepiride on Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes: The PERISCOPE Randomized Controlled Trial Steven E. Nissen; Stephen J. Nicholls; Kathy Wolski; Richard Nesto; Stuart Kupfer; Alfonso Perez; Horacio Jure; Robert De Larochellière; Cezar S. Staniloae; Kreton Mavromatis; Jacqueline Saw; Bo Hu; A. Michael Lincoff; E. Murat Tuzcu; for the PERISCOPE Investigators JAMA. 2008;299(13):1561-1573. Published online March 31, 2008 (doi:10.1001/jama.299.13.1561). Gene Expression Signatures, Clinicopathological Features, and Individualized Therapy in Breast Cancer Chaitanya R. Acharya; David S. Hsu; Carey K. Anders; Ariel Anguiano; Kelly H. Salter; Kelli S. Walters; Richard C. Redman; Sascha A. Tuchman; Cynthia A. Moylan; Sayan Mukherjee; William T. Barry; Holly K. Dressman; Geoffrey S. Ginsburg; Kelly P. Marcom; Katherine S. Garman; Gary H. Lyman; Joseph R. Nevins; Anil Potti JAMA. 2008;299(13):1574-1587. Clinical Crossroads A 21-Year-Old Man With Chronic Pancreatitis Mark P. Callery; Steven D. Freedman JAMA. 2008;299(13):1588-1594. Published online March 4, 2008 (doi:10.1001/jama.299.9.jrr80001). Commentaries 21st-Century Primary Care: New Physician Roles Need New Payment Models Richard J. Baron; Christine K. Cassel JAMA. 2008;299(13):1595-1597. Newly Approved Does Not Always Mean New and Improved Geoffrey M. Anderson; David Juurlink; Allan S. Detsky JAMA. 2008;299(13):1598-1600. Editorials The Hope and Fear of Rimonabant John S. Rumsfeld; Brahmajee K. Nallamothu JAMA. 2008;299(13):1601-1602. Published online April 1, 2008 (doi:10.1001/jama.299.13.1601). Does PERISCOPE Provide a New Perspective on Diabetic Treatment? Philippe Gabriel Steg; Michel Marre JAMA. 2008;299(13):1603-1604. Published online March 31, 2008 (doi:10.1001/jama.299.13.1603). Use of Gene Signatures to Improve Risk Estimation in Cancer Chiang-Ching Huang; Markus Bredel JAMA. 2008;299(13):1605-1606. Roles Need New Payment Models Richard J. Baron; Christine K. Cassel JAMA. 2008;299(13):1595-1597. Newly Approved Does Not Always Mean New and Improved Geoffrey M. Anderson; David Juurlink; Allan S. Detsky JAMA. 2008;299(13):1598-1600. Editorials The Hope and Fear of Rimonabant John S. Rumsfeld; Brahmajee K. Nallamothu JAMA. 2008;299(13):1601-1602. Published online April 1, 2008 (doi:10.1001/jama.299.13.1601). Does PERISCOPE Provide a New Perspective on Diabetic Treatment? Philippe Gabriel Steg; Michel Marre JAMA. 2008;299(13):1603-1604. Published online March 31, 2008 (doi:10.1001/jama.299.13.1603). Use of Gene Signatures to Improve Risk Estimation in Cancer Chiang-Ching Huang; Markus Bredel JAMA. 2008;299(13):1605-1606.

uman Papillomavirus Infection and Cervical Cytology in Women Screened for Cervical Cancer in the United States, 2003–2005 Datta, Koutsky, Ratelle, Unger, Shlay, McClain, Weaver, Kerndt, and others Differences in Kidney Function and Incident Hypertension: The Multi-Ethnic Study of Atherosclerosis Kestenbaum, Rudser, de Boer, Peralta, Fried, Shlipak, Palmas, and others Comparison of 2 Interventions for Liquid Aspiration on Pneumonia Incidence: A Randomized Trial Robbins, Gensler, Hind, Logemann, Lindblad, Brandt, Baum, Lilienfeld, and others ACADEMIA AND CLINIC Exploring the Geometry of Treatment Networks Salanti, Kavvoura, and Ioannidis REVIEW Systematic Review: The Effect of Preventive Lamivudine on Hepatitis B Reactivation during Chemotherapy Loomba, Rowley, Wesley, Liang, Hoofnagle, Pucino, and Csako PERSPECTIVE The Case for Treating Tobacco Dependence as a Chronic Disease Steinberg, Schmelzer, Richardson, and Foulds Author interview: CLINICAL GUIDELINES Screening for Chronic Obstructive Pulmonary Disease Using Spirometry: U.S. Preventive Services Task Force Recommendation Statement U.S. Preventive Services Task Force Screening for Chronic Obstructive Pulmonary Disease Using Spirometry: Summary of the Evidence for the U.S. Preventive Services Task Force Lin, Watkins, Johnson, Rodriguez, and Barton EDITORIAL Adding Human Papillomavirus Testing to Cytology for Primary Cervical Cancer Screening: Shooting First and Asking Questions Later Sawaya IN THE CLINIC Dementia

Seminar author Murray Stein from the University of California San Diego, USA, discusses social anxiety disorder, also known as social phobia, in this week's podcast. While causes remain uncertain, diagnosis and treatment are relatively straightforward, although the disorder needs greater awareness among the estimated 5% of the population who experience social anxiety, and among physicians who can help treat the condition.

5 of 54 episodes displayed
View All Episodes >
(49 more)